Biomedical Research
Online ISSN : 1880-313X
Print ISSN : 0388-6107
ISSN-L : 0388-6107
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The combined effects of genetic variations in the GPR120 gene and dietary fat intake on obesity risk
Toshiharu WAGURIToshinao GODANobuhiko KASEZAWAKimiko YAMAKAWA-KOBAYASHI
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2013 Volume 34 Issue 2 Pages 69-74

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Abstract

Obesity is a complex multifactorial disorder resulting from the action and interaction of many genetic factors and environmental factors. Recently, it has become clear that inflammation is a key feature of obesity. Long-chain ω-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects, and the G protein-coupled receptor GPR120 was reported to mediate the anti-inflammatory effects of ω-3 PUFAs. In addition, it was reported that GPR120 is involved in the development of obesity in mice and humans. In this study, we investigated whether common genetic variants of the GPR120 gene could influence the risk of obesity in a Japanese population. Our data suggest that the combination of common genetic variations in the GPR120 gene and dietary fat intake is a possible determinant of body mass index.

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© 2013 Biomedical Research Press
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