Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Tohru SAKAI; Tomoyo TAKI; Akiko NAKAMOTO; Emi SHUTO; Rie TSUTSUMI; Takayuki TOSHIMITSU; Seiya MAKINO; Shuuji IKEGAMI

doi:10.3177/jnsv.59.144

Note

Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet

Tohru SAKAI, Tomoyo TAKI, Akiko NAKAMOTO, Emi SHUTO, Rie TSUTSUMI, Takayuki TOSHIMITSU, Seiya MAKINO, Shuuji IKEGAMI

Author information

Tohru SAKAI
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Tomoyo TAKI
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Akiko NAKAMOTO
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Emi SHUTO
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Rie TSUTSUMI
Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
Takayuki TOSHIMITSU
Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Corporation
Seiya MAKINO
Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Corporation
Shuuji IKEGAMI
Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Corporation

Keywords: Lactobacillus plantarum, obesity, inflammation, adipose tissue

JOURNAL FREE ACCESS

2013 Volume 59 Issue 2 Pages 144-147

DOI https://doi.org/10.3177/jnsv.59.144

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Abstract

The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity. Mice that had been administered 10⁹ cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1β in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.

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