Primary Central Nervous System Lymphoma in Miyazaki, Southwestern Japan, a Human T-Lymphotropic Virus Type-1 (HTLV-1)-Endemic Area: Clinicopathological Review of 31 Cases

Kazunari Maekawa; Sayaka Moriguchi-Goto; Ayako Kamiunten; Yoko Kubuki; Kazuya Shimoda; Hideo Takeshima; Yujiro Asada; Kousuke Marutsuka

doi:10.3960/jslrt.54.179

Original Article

Primary Central Nervous System Lymphoma in Miyazaki, Southwestern Japan, a Human T-Lymphotropic Virus Type-1 (HTLV-1)-Endemic Area: Clinicopathological Review of 31 Cases

Kazunari Maekawa, Sayaka Moriguchi-Goto, Ayako Kamiunten, Yoko Kubuki, Kazuya Shimoda, Hideo Takeshima, Yujiro Asada, Kousuke Marutsuka

Author information

Kazunari Maekawa
Department of Diagnostic Pathology, Faculty of Medicine, University of Miyazaki Hospital
Sayaka Moriguchi-Goto
Department of Diagnostic Pathology, Faculty of Medicine, University of Miyazaki Hospital
Ayako Kamiunten
Department of Internal Medicine, Faculty of Medicine, University of Miyazaki Hospital
Yoko Kubuki
Department of Internal Medicine, Faculty of Medicine, University of Miyazaki Hospital
Kazuya Shimoda
Department of Internal Medicine, Faculty of Medicine, University of Miyazaki Hospital
Hideo Takeshima
Department of Neurosurgery, Faculty of Medicine, University of Miyazaki Hospital
Yujiro Asada
Department of Diagnostic Pathology, Faculty of Medicine, University of Miyazaki Hospital
Kousuke Marutsuka
Department of Diagnostic Pathology, Faculty of Medicine, University of Miyazaki Hospital

Keywords: B-cell lymphoma, human T-lymphotropic virus type 1, primary central nervous system lymphoma, T-cell lymphoma

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2014 Volume 54 Issue 3 Pages 179-185

DOI https://doi.org/10.3960/jslrt.54.179

Details

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive brain tumor. The aim of this study was to clarify the prevalence of T-cell-type PCNSL (T-PCNSL) in a human T-lymphotropic virus type-1 (HTLV-1)-endemic area of Southwestern Japan. We retrospectively investigated 31 PCNSL cases diagnosed between 1996 and 2013 at the University of Miyazaki Hospital. These cases accounted for 4.4% of all nodal or extranodal malignant lymphomas. Histologically, most of these cases were diagnosed as diffuse large B-cell lymphoma, while only two cases were considered to be low-grade and high-grade B-cell lymphoma (not otherwise specified). No T-PCNSL was found in this series. In addition, Epstein-Barr virus-encoded RNAs were not detected by in situ hybridization in any of the cases. Overall, no T-PCNSL cases were found in 18 years in a region with a high frequency of HTLV-1 seropositivity, namely, Southwestern Japan. This suggests that PCNSL and lymphomas of other anatomical sites are biologically distinct.

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