Longitudinal Monitoring with Multiple MR Techniques in a Case of Progressive Multifocal Leukoencephalopathy Associated with Multiple Myeloma

Majigsuren MUNGUNKHUYAG; Masafumi HARADA; Takashi ABE; Koji FUJITA; Naoko MATSUI; Ryuji KAJI

doi:10.2463/mrms.2013-0037

Case Reports

Longitudinal Monitoring with Multiple MR Techniques in a Case of Progressive Multifocal Leukoencephalopathy Associated with Multiple Myeloma

Majigsuren MUNGUNKHUYAG, Masafumi HARADA , Takashi ABE, Koji FUJITA, Naoko MATSUI, Ryuji KAJI

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Keywords: fractional anisotropy (FA), JC virus (JCV), progressive multifocal leukoencephalopathy (PML), proton magnetic resonance spectroscopy (MRS), pseudo-continuous arterial spin labeling (pCASL)

JOURNAL OPEN ACCESS

2014 Volume 13 Issue 1 Pages 55-59

DOI https://doi.org/10.2463/mrms.2013-0037

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Abstract

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus in immunocompromised patients. We report characteristic features of proton MR spectroscopy, 3-dimensional pseudo-continuous arterial spin labeling imaging, and diffusion tensor imaging in a 53-year-old patient with PML. The utility of multi-modal magnetic resonance techniques for longitudinal monitoring was indicated by their reevaluation over time and consideration of their relation to prognosis.

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