The mass sensitivity of quartz-crystal microbalance (QCM) was drastically improved by removing electrodes and wires attached on the quartz surfaces. Instead of wire connections, intended vibrations of quartz oscillators were excited and detected by antennas through electromagnetic waves. This noncontacting measurement is the key for ultrahigh-sensitive detection of proteins in liquids as well as quantitative measurements. This review shows the principle of wireless QCMs, their applications to studying interactions among biomolecules and aggregation reactions of amyloid β peptides, and the next-generation MEMS QCM, the resonance acoustic microbalance with naked embedded quartz (RAMNE-Q).

(Communicated by Shun-ichi IWASAKI, M.J.A.)