The research in this paper studies the effect of the response of upper structure and soil deformation on the overall behavior of structure through static and dynamic analyses. Several structures with pile foundations, such as bridge pier, viaduct and isolated bridge, were assumed to be constructed on a soil of good condition. The soil deposit characters were selected so that their deformations could be regarded as negligible in the design standard, whereas their shear velocity and resulting strain would change drastically with the depth. It was clarified through series of simulations that response of soils significantly affects the moment distributions of piles, regardless of the amount of response of superstructures. It consequently follows that the soil behavior should be properly considered even under good soil condition.