Japanese Journal of Infectious Diseases
Online ISSN : 1884-2836
Print ISSN : 1344-6304
ISSN-L : 1344-6304
Original Article
Pandemic Influenza A (H1N1) Infection in Pregnant and Nonpregnant Women in Spain (2009–2010)
María Morales Suárez-Varela, Fernando González-Candelas, Jenaro Astray, Jordi Alonso, Olatz Garin, Ady Castro, Juan C. Galán, Maretva Baricot, Jesús Castilla, Pere Godoy, Miguel Delgado-Rodríguez, Vicente Martin, José M. Mayoral, Tomás Pumarola, José M. Quintana, Sonia Tamames, Agustín Llopis-González, Àngela Dominguez, the CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
Author information
Keywords: pandemic influenza, pregnant women, risk factors, Spain
JOURNAL FREE ACCESS

2014 Volume 67 Issue 3 Pages 163-171

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Abstract

The present study aimed to compare the main features of infection with pandemic influenza A virus in pregnant and nonpregnant women admitted to hospitals in Spain during the first waves of the 2009–2010 influenza pandemic. This was a prospective (November 2009 to June 2010), multicenter observational study. All cases were women of reproductive age who had not been vaccinated against seasonal or pandemic influenza A. Influenza infection was confirmed by reverse transcription-polymerase chain reaction (RT-PCR). The sociodemographic and clinical data of all cases were reviewed. A total of 219 inpatients, including 49 pregnant women and 170 nonpregnant women, were enrolled in the study upon admission to participating hospitals. The most substantially different symptoms between the groups were respiratory distress and unilobar consolidation, both of which were more frequent among nonpregnant women. Antibiotics and systemic corticosteroids were more frequently used in nonpregnant women; however, there were no differences in the rates of treatment with antivirals. Our findings indicated that the compared with nonpregnant women, pregnant women in this study did not have significantly different symptoms and were not at increased risk of complications from pandemic influenza virus infection.

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