Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats

Koichi Abe; Norihisa Okada; Hiroki Tanabe; Ryuuta Fukutomi; Kensuke Yasui; Mamoru Isemura; Naohide Kinae

doi:10.2220/biomedres.30.25

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Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats

Koichi Abe, Norihisa Okada, Hiroki Tanabe, Ryuuta Fukutomi, Kensuke Yasui, Mamoru Isemura, Naohide Kinae

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JOURNAL FREE ACCESS

2009 Volume 30 Issue 1 Pages 25-29

DOI https://doi.org/10.2220/biomedres.30.25

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Abstract

Normal rats were given catechin-rich green tea as drinking fluid and the effects on hepatic gene expression were examined. The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor α in the rats given green tea for 4 weeks as compared with the water-given animals. One may expect anti-diabetic activity by catechin-rich green tea through its chronic down-regulatory effect on G6Pase expression.

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