FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
Online ISSN : 2185-4610
Print ISSN : 0016-2590
ISSN-L : 0016-2590
Original Articles
FLOW-MEDIATED DILATATION IDENTIFIES IMPAIRED ENDOTHELIAL FUNCTION IN PATIENTS WITH SLEEP APNEA SYNDROME
AKIOMI YOSHIHISATAKASHI OWADAYASUTO HOSHINOMAKIKO MIYATATOMOFUMI MISAKATAKAMASA SATOSATOSHI SUZUKINOBUO SAKAMOTOKOICHI SUGIMOTOHIROYUKI KUNIIKAZUHIKO NAKAZATOHITOSHI SUZUKISHU-ICHI SAITOHTOSHIYUKI ISHIBASHIYASUCHIKA TAKEISHI
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2010 Volume 56 Issue 2 Pages 115-120

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Abstract

[Background] Non-invasive detection of vascular dysfunction in the early stage is clinically important in patients with sleep apnea syndrome (SAS). Flow-mediated dilatation (FMD) is a novel clinical marker of endothelial function. However, it is not clear whether this is useful in the SAS patient. [Methods] Echocardiographic parameters and FMD were measured in 129 patients with SAS. Apnea-hypopnea index (AHI) was defined by polygraphy, and patients were divided into the two Groups: Group A (moderate-severe SAS: AHI≥ 15 times/hr, n=93) and Group B (mild SAS: AHI 5-15 times/hr, n=36). [Results] There were no significant differences in echocardiographic parameters between the two groups. However, FMD was significantly lower in Group A than in Group B (3.5±1.6 vs. 7.8±3.1, P< 0.01). [Conclusions] Although cardiac function was not different, vascular dysfunction was evident in patients with moderate-severe SAS. FMD is a useful tool to identify impaired endothelial function non-invasively in patients with SAS.

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© 2010 The Fukushima Society of Medical Science

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