Robertsonian metacentrics of the house musk shrew (Suncus murinus, Insectivora, Soricidae) lose the telomeric sequences in the centromeric area.

Margarita B. Rogatcheva; Takao Ono; Shin-ichi Sonta; Sen-ichi Oda; Pavel M. Borodin

doi:10.1266/ggs.75.155

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Robertsonian metacentrics of the house musk shrew (Suncus murinus, Insectivora, Soricidae) lose the telomeric sequences in the centromeric area.

Margarita B. Rogatcheva, Takao Ono, Shin-ichi Sonta, Sen-ichi Oda, Pavel M. Borodin

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JOURNAL FREE ACCESS

2000 Volume 75 Issue 3 Pages 155-158

DOI https://doi.org/10.1266/ggs.75.155

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Abstract

The house musk shrew, Suncus murinus, is polymorphic for five Robertsonian translocations (Rb8.17, 9.13, 10.12, 11.16, 14.15). Fluorescence in situ hybridisation with a biotin-labelled oligonucleotide, (TTAGGG)₇, was performed to localise the telomeric DNA sequences at Rb chromosomes of heterozygous shrews. Hybridisation signals were observed at both ends of all chromosomes, but not at the pericentromeric areas of any of the Robertsonian metacentrics. Our results indicate a complete loss of the telomeric sequences at the fusion points of the Rb metacentrics in S. murinus.

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