Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Hematological Diseases
Human Herpes Virus 8-negative Primary Effusion Lymphoma (PEL) in a Patient after Repeated Chylous Ascites and Chylothorax
Atsushi NONAMIToshihiro YOKOYAMAMorishige TAKESHITAKoichi OHSHIMAAkira KUBOTASeiichi OKAMURA
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JOURNAL OPEN ACCESS

2004 Volume 43 Issue 3 Pages 236-242

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Abstract

We describe a case of malignant lymphoma which presented in the body cavities without identifiable tumor masses. Malignant lymphoma cells showed strong atypia with prominent nuclei and basophilic cytoplasm containing vacuoles. The chromosomes showed diploidy and complex abnormalities including translocations and deletions. We diagnosed this patient with primary effusion lymphoma (PEL), even though she tested negative for human herpes virus-8 (HHV-8) which has been suggested to be causally related to PEL. Interestingly, the patient also showed complicated protein-losing enteropathy, and PEL occurred after repeated chylous ascites and chylothorax. The possible pathogenesis of this rare disease is discussed here.

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© 2004 by The Japanese Society of Internal Medicine
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