Ampulla Cardiomyopathy after Hypoglycemia in Three Young Female Patients with Anorexia Nervosa

Rina OHWADA; Mari HOTTA; Hironari KIMURA; Sachiko TAKAGI; Naoki MATSUDA; Kaoru NOMURA; Kazue TAKANO

doi:10.2169/internalmedicine.44.228

CASE REPORTS

Ampulla Cardiomyopathy after Hypoglycemia in Three Young Female Patients with Anorexia Nervosa

Rina OHWADA, Mari HOTTA, Hironari KIMURA, Sachiko TAKAGI, Naoki MATSUDA, Kaoru NOMURA, Kazue TAKANO

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Keywords: anorexia nervosa, hypoglycemia, ampulla cardiomyopathy (Takotsubo-like cardiomyopathy), reversible myocardial dysfunction

JOURNAL OPEN ACCESS

2005 Volume 44 Issue 3 Pages 228-233

DOI https://doi.org/10.2169/internalmedicine.44.228

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Abstract

Ampulla cardiomyopathy is named after the echocardiographic abnormalities occurring in this condition, characterized by extensive akinesis (ballooning ) of the apical region with hypercontraction of the basal segment of the ventricle. We describe 3 young female anorexia nervosa patients showing evidence of this cardiac complication after hypoglycemia. One case was complicated by echocardiographically confirmed ampulla cardiomyopathy while the other 2 patients showed increases in myocardial enzymes and transient electrocardiographic abnormalities consistent with this complication. The precipitating event for all three patients was hypoglycemic coma, and this is the first case report in which this factor lead to the complication of ampulla cardiomyopathy in anorexia nervosa patients.

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