Two Cases of Mediastinal Gray Zone Lymphoma

Jiro Minami; Nobuaki Dobashi; Osamu Asai; Shingo Yano; Hiroshi Osawa; Yutaka Takei; Yuichi Yahagi; Shinobu Takahara; Yoji Ogasawara; Yuko Yamaguchi; Tatsunosuke Kobayashi; Noriyuki Morikawa; Takashi Nikaido; Keisuke Aiba; Noriko Usui

doi:10.3960/jslrt.50.143

Case Study

Two Cases of Mediastinal Gray Zone Lymphoma

Jiro Minami, Nobuaki Dobashi, Osamu Asai, Shingo Yano, Hiroshi Osawa, Yutaka Takei, Yuichi Yahagi, Shinobu Takahara, Yoji Ogasawara, Yuko Yamaguchi, Tatsunosuke Kobayashi, Noriyuki Morikawa, Takashi Nikaido, Keisuke Aiba, Noriko Usui

Author information

Jiro Minami
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Nobuaki Dobashi
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Osamu Asai
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Shingo Yano
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Hiroshi Osawa
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Yutaka Takei
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Yuichi Yahagi
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Shinobu Takahara
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Yoji Ogasawara
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Yuko Yamaguchi
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Tatsunosuke Kobayashi
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Noriyuki Morikawa
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Takashi Nikaido
Department of Pathology, Jikei University School of Medicine
Keisuke Aiba
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine
Noriko Usui
Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine

Keywords: mediastinal gray zone lymphoma, composite lymphoma, nodular sclerosis classical Hodgkin lymphoma, mediastinal large B-cell lymphoma, autologous peripheral blood stem cell transplantation

JOURNAL FREE ACCESS

2010 Volume 50 Issue 2 Pages 143-149

DOI https://doi.org/10.3960/jslrt.50.143

Details

Abstract

Mediastinal gray zone lymphoma (MGZL) represents a range of tumors possessing characteristics of both nodular sclerosis classical Hodgkin lymphoma (NSHL) and mediastinal large B-cell lymphoma (MLBCL). Here we report two patients with MGZL. Patient 1 was a 30-year-old woman and patient 2 was a 22-year-old man. Both patients had a mediastinal mass, were initially diagnosed with NSHL and exhibited resistance to first-line chemotherapy. Re-biopsy of the relapsed tumors or the residual lesion was performed and based on the findings the tumors were diagnosed as MGZL. In patient 1, the morphological features of the tumor resembled those of NSHL, but the immunophenotypic features indicated MLBCL. In patient 2, the tumor was a composite lymphoma with both NSHL and MLBCL components. Both the patients received high-dose chemotherapy followed by autologous peripheral-blood stem-cell transplantation. Although there is an overlap in the biological and morphological features between NSHL and MLBCL, the therapeutic approaches to NSHL and MLBCL are quite different. The development of effective therapies for MGZL is therefore extremely critical.

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