The palladium-catalyzed cross-coupling reaction between different types of organoboron compounds with sp²-, sp³-, and sp-hybridized carbon-boron compounds and various organic electrophiles in the presence of base provides a powerful and useful synthetic methodology for the formation of carbon-carbon bonds. The coupling reaction offers several advantages:
(1) Availability of reactants
(2) Mild reaction conditions
(3) Water stability
(4) Easy use of the reaction both in aqueous and heterogeneous conditions
(5) Tolerance of a broad range of functional groups
(6) High regio- and stereoselectivity
(7) Insignificant effect toward steric hindrance
(8) Use of very small amounts of catalysts
(9) Utilization as one-pot synthesis
(10) Non-toxic reaction


(Communicated by Teruaki MUKAIYAMA, M.J.A.)