2009 Volume 85 Issue 4 Pages 143-156
Mammalian immune response can be divided into innate and acquired immunity. Furthermore, much evidence has demonstrated that activation of innate immunity is a prerequisite to induction of acquired immunity. This paradigm shift has changed our thinking on the pathogenesis and treatment of infections, immune diseases, allergy, and cancers.
(Communicated by Tadamitsu KISHIMOTO, M.J.A.)