Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity

Kiyoyuki YAMADA; Makoto OJIKA; Hideo KIGOSHI; Kiyotake SUENAGA

doi:10.2183/pjab.86.176

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Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity

Kiyoyuki YAMADA, Makoto OJIKA, Hideo KIGOSHI, Kiyotake SUENAGA

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Keywords: cytotoxic substances, sea hare, isolation, chemical structure, chemical synthesis, antitumor activity

JOURNAL FREE ACCESS

2010 Volume 86 Issue 3 Pages 176-189

DOI https://doi.org/10.2183/pjab.86.176

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Abstract

From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.

(Communicated by Satoshi OMURA, M.J.A.)

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