The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Regular Contributions
Lactation and Risk of Endometrial Cancer in Japan: A Case-Control Study
Chikako OkamuraYoshitaka TsubonoKiyoshi ItoHitoshi NiikuraTadao TakanoSatoru NagaseKohsuke YoshinagaYukihiro TeradaTakashi MurakamiShinji SatoDaisuke AokiToshiko JoboKunihiro OkamuraNobuo Yaegashi
Author information
JOURNAL FREE ACCESS

2006 Volume 208 Issue 2 Pages 109-115

Details
Abstract

The incidence of endometrial cancer is rapidly increasing in Japan. Although the risk factors in European populations have been well described, there are few epidemiologic studies regarding risk factors for endometrial cancer in Japanese women. This hospital-based case-control study among Japanese women was carried out from 1998 to 2000. The cases were selected from women with endometrial cancer (n =155), and the controls selected from women attending the university gynecological outpatient clinic for cervical cancer screening (n = 96). Subjects were interviewed to ascertain breast feeding practices, contraceptive usage, as well as potential risk factors for endometrial cancer. We observed a lower risk of endometrial cancer associated with oral contraceptive (OC) and a higher risk associated with higher body mass index (BMI), and older ages at first and last delivery. Gravidity reduced odds ratio (OR) for endometerial cancer to 0.34 (95% confidence interval [CI] 0.13-0.92). Compared with parous women who had never breastfed, the multivariate OR for women with a history of breastfeeding was 0.37 (95% CI, 0.17-0.82). Additionally, a greater lapse of time since breastfeeding increased OR for endometrial cancer by over three times. In conclusion, the present study has indicated that breastfeeding reduces the risk of endometrial cancer in Japanese women.

Content from these authors
© 2006 Tohoku University Medical Press
Previous article Next article
feedback
Top