Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of P53 on Urinary Bladder Carcinogenesis

Naomi Ishii; Min Wei; Anna Kakehashi; Kenichiro Doi; Shotaro Yamano; Masaaki Inaba; Hideki Wanibuchi

doi:10.1293/tox.24.25

Originals

Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of P53 on Urinary Bladder Carcinogenesis

Naomi Ishii, Min Wei, Anna Kakehashi, Kenichiro Doi, Shotaro Yamano, Masaaki Inaba, Hideki Wanibuchi

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Keywords: type 2 diabetes mellitus, bladder carcinogenesis, PI3K, p53

JOURNAL FREE ACCESS

2011 Volume 24 Issue 1 Pages 25-36

DOI https://doi.org/10.1293/tox.24.25

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Abstract

In the present study, modifying effects of diabetes on carcinogenesis induced in type 2 diabetes mellitus model Zucker diabetic fatty (ZDF) rats were investigated using a multiorgan carcinogenesis bioassay. Our results demonstrated enhancement of urinary bladder, colon and liver carcinogenesis in ZDF rats treated with five types of carcinogens (DMBDD). Elevated insulin and leptin and decreased adiponectin levels in the serum may be responsible for the high susceptibility of type 2 diabetes mellitus model rats to carcinogenesis in these organs. Possible mechanisms of increased susceptibility of diabetic rats to bladder carcinogenesis could be activation of the PI3K pathway and suppression of p53 in the urothelium in consequence of the above serum protein alterations.

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