γ線照射ジャガイモのアルコール抽出物の変異原性に関する研究 ―細菌および哺乳動物細胞による試験―

石館 基; 吉川 邦衛; 祖父尼 俊雄; 岩原 繁雄; 渋谷 徹; 村松 晉; 北山 滋; 松山 晃

doi:10.3769/radioisotopes.30.12_662

Mutagenicity Studies on Alcohol Extracts from Gamma-Irradiated Potatoes

—Tests for biological activities in bacterial and mammalian cell systems—

Motoi ISHIDATE, Kunie YOSHIKAWA, Toshio SOFUNI, Shigeo IWAHARA, Tohru SIBUYA, Susumu MURAMATSU, Shigeru KITAYAMA, Akira MATSUYAMA

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Keywords: irradiated potatoes, bacterial mutation, inductest, chromosomal aberration, micronucleus test

JOURNAL FREE ACCESS

1981 Volume 30 Issue 12 Pages 662-668

DOI https://doi.org/10.3769/radioisotopes.30.12_662

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Abstract

The alcohol extracts freshly prepared from gamma-irradiated potatoes were examined for their mutagenic activity in bacterial and mammalian cell systems. Negative results were obtained from all following test systems: Mutation assays with Salmonella typhimurium His^- strains such as TA 100, TA 98, TA 1535, TA 1537, and streptomycin-dependent mutant (SM^d) strain, TA 100-10, inductests with Escherichia coli strains, K 12 GY 5027 and K 12 C600, chromosomal aberration tests with Chinese hamster cells in culture, as well as micronucleus tests in mice. In addition, no difference in the mutagenic activities was found between extracts prepared from the irradiated and the unirradiated potatoes, suggesting that no mutagenic substance was produced in potatoes following gamma-irradiation.

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