The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Clinical Study of Cardiac Arrhythmias Using a 24-Hour Continuous Electrocardiographic Recorder (5th Report) - Antiarrhythmic Action of Coenzyme Q10 in Diabetics
TOSHIHIRO FUJIOKAYASUHIRO SAKAMOTOGORO MIMURA
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1983 Volume 141 Issue Suppl Pages 453-463

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Abstract

An investigation was undertaken to evaluate the antiarrhythmic effect of CoQ10 on VPBs using the Holter ECG, in 27 patients with no clinical findings of organic cardiopathies. As a result, the effect of CoQ10 on VPBs was considered beneficial in 6 (22%) of 27 cases, consisting of 1 patient with hypertension and 5 patients with DM. Even in the remaining 2 patients with DM, the frequency of VPBs was reduced by 50% or more during treatement with CoQ10. The mean reduction of VPBs frequency in the 5 responders plus these 2 patients with DM was 85.7%. These findings suggest that CoQ10 exhibits an effective antiarrhythmic action not merely on organic heart disease but also on VPBs supervening on DM.

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