A Definite Case of L-carbocisteine-induced Pneumonia with CATCH22 Syndrome

Kenichiro Kudo; Eiki Ichihara; Akiko Hisamoto; Katsuyuki Hotta; Nobuaki Miyahara; Yasushi Tanimoto; Sadaharu Akagi; Katsuya Kato; Mitsune Tanimoto; Katsuyuki Kiura

doi:10.2169/internalmedicine.52.7882

CASE REPORTS

A Definite Case of _L-carbocisteine-induced Pneumonia with CATCH22 Syndrome

Kenichiro Kudo, Eiki Ichihara, Akiko Hisamoto, Katsuyuki Hotta, Nobuaki Miyahara, Yasushi Tanimoto, Sadaharu Akagi, Katsuya Kato, Mitsune Tanimoto, Katsuyuki Kiura

Author information

Kenichiro Kudo
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan
Eiki Ichihara
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan
Akiko Hisamoto
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan
Katsuyuki Hotta
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan
Nobuaki Miyahara
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan
Yasushi Tanimoto
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan
Sadaharu Akagi
Department of Cardiovascular Surgery, Okayama University Hospital, Japan
Katsuya Kato
Department of Radiology, Okayama University Hospital, Japan
Mitsune Tanimoto
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
Katsuyuki Kiura
Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan

Keywords: drug-induced pneumonia, _L-carbocisteine, CATCH22 syndrome, drug-induced lymphocyte stimulation test

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 1 Pages 97-100

DOI https://doi.org/10.2169/internalmedicine.52.7882

Details

Abstract

A 32-year-old male with CATCH22 syndrome presented with a high fever and productive cough after taking drugs for acute bronchitis, including _L-carbocisteine. Chest radiography revealed ground-glass opacities in the bilateral lung fields. He had a history of similar pneumonia. Under the assumption of drug-induced pneumonia, or bacterial or viral pneumonia, all drugs including _L-carbocisteine were discontinued, and antibiotics were started. A drug-induced lymphocyte stimulation test was positive only for _L-carbocisteine. The only drug in common between this and the previous episode of pneumonia was _L-carbocisteine. We thus concluded that this was a definite case of _L-carbocisteine-induced pneumonia in a patient with CATCH22 syndrome.

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