Pulmonary Veno-occlusive Disease Following Reduced-intensity Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

Kohei Hosokawa; Hirohito Yamazaki; Masaru Nishitsuji; Satoshi Kobayashi; Akiyoshi Takami; Masaki Fujimura; Shinji Nakao

doi:10.2169/internalmedicine.51.6302

CASE REPORTS

Pulmonary Veno-occlusive Disease Following Reduced-intensity Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

Kohei Hosokawa, Hirohito Yamazaki, Masaru Nishitsuji, Satoshi Kobayashi, Akiyoshi Takami, Masaki Fujimura, Shinji Nakao

Author information

Keywords: acute myeloid leukemia, gemtuzumab ozogamicin, pulmonary, veno-occlusive disease, reduced-intensity transplantation

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 2 Pages 195-198

DOI https://doi.org/10.2169/internalmedicine.51.6302

Details

Abstract

We report a case of pulmonary veno-occlusive disease (PVOD) following allogeneic bone marrow transplantation (BMT) for the treatment of acute myeloid leukemia (AML) from an HLA mismatched mother using a reduced-intensity conditioning (RIC) regimen including gemtuzumab ozogamicin. The patient was a 21-year-old male who complained of dyspnea with hypoxemia followed by loss of consciousness. The abnormalities in chest CT and echocardiography were compatible with a diagnosis of PVOD. Treatment with 1 mg/kg of oral prednisolone resolved dyspnea and hypoxemia within a few days, and chest CT abnormalities disappeared in a week. This report is the first to describe PVOD following RIC stem cell transplantation.

Corresponding author

Register with J-STAGE for free!