ハトムギ熱水抽出物のラット 28 日間反復経口投与毒性試験

林 浩孝; 新井 隆成; STRONG Jeffry Michael; 徳田 春邦; 島野 康子; 太田 康之; 榎本 俊樹; 上馬塲 和夫; 太田 富久; 鈴木 信孝

doi:10.1625/jcam.6.131

Original Article

28-day Repeated Dose Oral Toxicity Test of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats

Hirotaka HAYASHI, Takanari ARAI, Jeffry M. STRONG, Harukuni TOKUDA, Yasuko SHIMANO, Yasuyuki OHTA, Toshiki ENOMOTO, Kazuo UEBABA, Tomihisa OHTA, Nobutaka SUZUKI

Author information

Hirotaka HAYASHI
Center for Innovation, Kanazawa University
Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
Takanari ARAI
Endowed Center for the Advancement of Pregnancy, Perinatal and Infant Care, Kanazawa University Graduate School of Medical Science
Jeffry M. STRONG
Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
Harukuni TOKUDA
Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
Yasuko SHIMANO
Graduate School of Natural Science and Technology, Kanazawa University
Yasuyuki OHTA
Graduate School of Natural Science and Technology, Kanazawa University
Toshiki ENOMOTO
Department of Food Science, Ishikawa Prefectural University
Kazuo UEBABA
Department of Presymptomatic Health Promotion Institute of Natural Medicine, University of Toyama
Tomihisa OHTA
Graduate School of Natural Science and Technology, Kanazawa University
Nobutaka SUZUKI
Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University

Keywords: Coix lacryma-jobi L. var.ma-yuen Stapf, Coix seed, safety test, subacute toxicity test, rat

JOURNAL FREE ACCESS

2009 Volume 6 Issue 3 Pages 131-135

DOI https://doi.org/10.1625/jcam.6.131

Details

Abstract

Coix lacryma-jobi L. var.ma-yuen Stapf (coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of coix seed has rarely been evaluated. We performed a 28-day repeated dose oral toxicity test of hot water extract of all parts of Coix seed in rats. The extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.

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