To compare qualitative and quantitative measures of the contrast-enhanced dual-echo Dixon technique with the commonly used standard three-dimensional(3D)gradient echo(GRE)using spectrally selective fat suppression technique in breast MRI. Dixon and standard fat suppression techniques were compared with phantom and clinical images. A total of 16 women, who underwent the breast MRI, were recruited to our study. For quantitative assessment, we calculated the coefficient of variance(CV)of fat region and contrast between fat region, normal tissue, and lesion on MR images acquired using Dixon technique and spectrally selective fat suppression technique. The CV of Dixon image was significantly higher than that of 3D-GRE images.(P < 0.05). Contrast between fat region and normal tissue and between fat region and lesion for Dixon images were also higher than were 3D-GRE images(P < 0.001). Dixon technique showed greater degree of fat suppression and image uniformity. Dixon technique was superior to the spectrally selective fat suppression technique in breast MRI.