Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Apheresis Therapy for Prolonged Red Cell Aplasia after Major ABO-Mismatched Bone Marrow Transplantation
Satoshi OHTAHitoshi YOKOYAMATakuyuki ISEKazuya TAKASAWATakashi WADASinji NAKAOTamotsu MATSUDAKen-ichi KOBAYASHI
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JOURNAL FREE ACCESS

1997 Volume 36 Issue 7 Pages 487-491

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Abstract

Two cases of leukemia were treated successfully with apheresis for delayed recovery of erythropoiesis due to antibody-mediated red cell aplasia after ABO-mismatched bone marrow transplantation (BMT). A 25-year-old female (ABO group O) underwent BMT from her brother (group A). Immunoadsorption using Biosynsorb A performed on day 146 after BMT followed by double filtration plasma pheresis (DFPP) reduced anti-A antibody titers from 1:32 to 1:2. Anemia improved dramatically within 2 weeks. A 49-year-old female (group O) underwent BMT from her mother (group A). She was treated with DFPP on day 131 after BMT. Anti-A antibody titers dropped from 1:16 to 1:1 and anemia improved gradually.
(Internal Medicine 36: 487-491, 1997)

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© The Japanese Society of Internal Medicine
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